Thioisonicotin amide



Patented Sept. 29, 1953 2,653,942

UNITED STATES PATENT OFFICE THIOISONICOTINAMIDE John Lee, Essex Fells, N. J., assignor to Hoffmann-La Roche Inc., Nutley, N. J., a. corporation of New Jersey No Drawing. Application August 15, 1951, Serial N0. 242,040

1 Claim. (Cl. 260-2943) 2 This invention relates to the new compound Example thwISPmCOtmamIde having the Structural for- 22 grams of isonicotinonitrile were dissolved in 200 cc. of methanol containing 20 per cent am- S monia by weight. The solution was saturated g 5 with hydrogen sulfide and permitted to stand at 25 C. for 48 hours. A yellow crystalline product separated which was recovered by filtration and recrystallized from hot water. The thioisonicotinamide thus obtained melted at 203-204 C.

\ 10 The compound is only slightly soluble in cold water.

The compound is useful in the field of therapeufi g gg tics, and more particularly as an antituberculous JOHN LEE compound. 15 Thioisonicotinamtide (rim1 realzlilyhbg prepareld References Cited in the file of this patent b reactin isonico inoni ri e wi y rogen su fi de in the presence of methanolic ammonia. UNITED STATES PATENTS The following example will serve to illustrate Number Name Date the preparation of thioisonicotinamlde. 20 2,560,046 Alliger July 10, 1951 

